Wright Josephine A, Brown David R
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.
J Neurosci Res. 2008 Feb 15;86(3):496-503. doi: 10.1002/jnr.21461.
Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals.
帕金森病和其他一些神经退行性疾病与一种名为α-突触核蛋白的蛋白质有关，该蛋白质可聚集并形成纤维。与许多其他与神经退行性疾病相关的蛋白质一样，这种蛋白质的功能尚不明确，其致病机制也不清楚。最近有研究表明它能结合铜。这篇综述评估了目前关于α-突触核蛋白及其与金属相互作用的已知信息。
