维生素E与丙酰-L-肉碱单独或联合应用于早期慢性佩罗尼氏病患者的比较：一项双盲、安慰剂对照的随机研究。

Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study.

作者信息

Safarinejad Mohammad Reza, Hosseini Seyyed Yousof, Kolahi Ali Asgar

机构信息

Urology and Nephrology Research Center, Faculty of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

J Urol. 2007 Oct;178(4 Pt 1):1398-403; discussion 1403. doi: 10.1016/j.juro.2007.05.162. Epub 2007 Aug 16.

DOI:10.1016/j.juro.2007.05.162

PMID:17706714

Abstract

PURPOSE

We compared the efficacy and safety of oral vitamin E and propionyl-L-carnitine, separately or in combination, for the treatment of Peyronie's disease.

MATERIALS AND METHODS

A total of 236 men (mean age 43.4 years) with Peyronie's disease were randomly assigned to 4 groups. Group 1 (58 men) received 300 mg vitamin E orally twice daily. Group 2 (59) received 1 gm propionyl-L-carnitine orally twice daily, and group 3 (60) received 300 mg vitamin E and 1 gm propionyl-L-carnitine orally twice daily. Group 4 (control group, 59 men) received a similar regimen of placebo during the 6-month treatment period. The efficacy of the 4 treatments was assessed using responses to the International Index of Erectile Function, visual analog scale for pain evaluation, mean intercourse satisfaction domain, mean weekly coitus episodes, penile curvature, plaque size and adverse drug effects.

RESULTS

Pain decreased in 60.4%, 63%, 62.3% and 59.2% of the patients treated with vitamin E, propionyl-L-carnitine, vitamin E plus propionyl-L-carnitine and placebo, respectively (p = 0.1). After therapy a reduction in penile curvature was observed by 18.9%, 20.4%, 22.6% and 18.4% of the patients in groups 1, 2, 3 and 4, respectively (p = 0.09), and a decrease in plaque size was noted in 11.3%, 12.9%, 13.2% and 11.1%, respectively (p = 0.1).

CONCLUSIONS

This study did not show significant improvement in pain, curvature or plaque size in patients with PD treated with vitamin E, propionyl-L-carnitine, or vitamin E plus propionyl-L-carnitine compared with those treated with placebo.

摘要

目的

我们比较了口服维生素E和丙酰-L-肉碱单独或联合使用治疗佩罗尼氏病的疗效和安全性。

材料与方法

总共236名患有佩罗尼氏病的男性（平均年龄43.4岁）被随机分为4组。第1组（58名男性）每天口服两次300毫克维生素E。第2组（59名）每天口服两次1克丙酰-L-肉碱，第3组（60名）每天口服两次300毫克维生素E和1克丙酰-L-肉碱。第4组（对照组，59名男性）在6个月的治疗期内接受类似的安慰剂治疗方案。使用国际勃起功能指数、疼痛评估视觉模拟量表、平均性交满意度领域、平均每周性交次数、阴茎弯曲度、斑块大小和药物不良反应来评估这4种治疗方法的疗效。

结果

分别接受维生素E、丙酰-L-肉碱、维生素E加丙酰-L-肉碱和安慰剂治疗的患者中，疼痛减轻的比例分别为60.4%、63%、62.3%和59.2%（p = 0.1）。治疗后，第1、2、3和4组中分别有18.9%、20.4%、22.6%和18.4%的患者阴茎弯曲度减小（p = 0.09），斑块大小减小的比例分别为11.3%、12.9%、13.2%和11.1%（p = 0.1）。