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输尿管囊肿相关膀胱输尿管反流的内镜治疗

Endoscopic treatment of vesicoureteral reflux associated with ureterocele.

作者信息

Chertin Boris, Mohanan Nochiparambil, Farkas Amicur, Puri Prem

机构信息

Department of Urology, Shaare Zedek Medical Centre, Jerusalem.

出版信息

J Urol. 2007 Oct;178(4 Pt 2):1594-7. doi: 10.1016/j.juro.2007.03.170. Epub 2007 Aug 16.

Abstract

PURPOSE

We determined the value of endoscopic treatment for vesicoureteral reflux associated with ureterocele.

MATERIALS AND METHODS

From 1984 to 2005, 109 children with a median age of 6 months underwent endoscopic ureterocele puncture. Ureterocele presented as a part of a duplex system in 97 of patients (89%) and as part of a single system in 12 (11%). Vesicoureteral reflux was seen to the lower ipsilateral moiety in 53 patients and in 32 contralateral kidneys (85 refluxing renal units). Puncture was performed with a 3Fr Bugbee electrode. High grade vesicoureteral reflux or breakthrough infection while on antibiotic prophylaxis served as the indication for the surgical correction of vesicoureteral reflux. Median followup after endoscopic correction was 10 years (range 1 to 21).

RESULTS

Spontaneous vesicoureteral reflux resolution following successful ureterocele puncture was seen in 36 of the 85 refluxing renal units (42%) and in 5 (6%) reflux was downgraded. The latter patients were withdrawn from antibiotic prophylaxis and they did well. A total of 33 refluxing renal units with vesicoureteral reflux into the lower moiety of the ureterocele kidney and 11 contralateral refluxing renal units underwent endoscopic correction. Reflux was corrected in 31 of the 44 refluxing renal units (70%) after a single injection and it resolved after a second injection in another 9 (21%). In 4 refluxing renal units (9%) endoscopic correction failed and open reimplantation was done. Of the 109 patients (13%) 14 had vesicoureteral reflux to the ureterocele moiety following endoscopic puncture. Of those patients endoscopic correction resolved reflux in 3, reflux resolved spontaneously in 5 and upper pole partial nephrectomy was performed in 4 due to a nonfunctioning moiety. The remaining 2 patients did well without antibiotic prophylaxis.

CONCLUSIONS

Our data show that endoscopic treatment of vesicoureteral reflux associated with ureterocele is a simple, long-term effective and safe procedure, avoiding the need for open surgery in the majority of patients following endoscopic puncture of ureterocele.

摘要

目的

我们确定了内镜治疗输尿管囊肿相关膀胱输尿管反流的价值。

材料与方法

1984年至2005年,109例中位年龄为6个月的儿童接受了内镜下输尿管囊肿穿刺。97例(89%)患者的输尿管囊肿是重复肾系统的一部分,12例(11%)是单一系统的一部分。53例患者同侧下半部出现膀胱输尿管反流,32例对侧肾脏出现反流(85个反流肾单位)。使用3Fr Bugbee电极进行穿刺。预防性使用抗生素时出现高级别膀胱输尿管反流或突破性感染是膀胱输尿管反流手术矫正的指征。内镜矫正后的中位随访时间为10年(范围1至21年)。

结果

85个反流肾单位中有36个(42%)在成功进行输尿管囊肿穿刺后膀胱输尿管反流自发消退,5个(6%)反流程度减轻。后一组患者停止预防性使用抗生素,情况良好。共有33个输尿管囊肿肾下半部出现膀胱输尿管反流的反流肾单位和11个对侧反流肾单位接受了内镜矫正。44个反流肾单位中有31个(70%)在单次注射后反流得到矫正,另外9个(21%)在第二次注射后反流消退。4个反流肾单位(9%)内镜矫正失败,进行了开放再植术。109例患者中有14例(13%)在经内镜穿刺后膀胱输尿管反流至输尿管囊肿部分。在这些患者中,3例经内镜矫正反流得到解决,5例反流自发消退,4例因上半部分无功能而进行了上极部分肾切除术。其余2例患者未进行预防性使用抗生素,情况良好。

结论

我们的数据表明,内镜治疗输尿管囊肿相关膀胱输尿管反流是一种简单、长期有效且安全的方法,在内镜穿刺输尿管囊肿后,大多数患者无需进行开放手术。

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