Lovett Susan T
Department of Biology and Rosenstiel Basic Medical Sciences Research Institute, MS029, Brandeis University, Waltham, MA 02454-9110, USA.
Mol Cell. 2007 Aug 17;27(4):523-6. doi: 10.1016/j.molcel.2007.08.003.
Our view of DNA replication has been of two coupled DNA polymerases anchored to the replication fork helicase in a "replisome" complex, synthesizing leading and lagging strands simultaneously. New evidence suggests that three DNA polymerases can be accommodated into the replisome and that polymerases and repair factors are dynamically recruited and engaged without dismantling of the replisome.
我们对DNA复制的看法一直是，在一个“复制体”复合物中，两个耦合的DNA聚合酶锚定在复制叉解旋酶上，同时合成前导链和后随链。新证据表明，复制体中可以容纳三种DNA聚合酶，并且聚合酶和修复因子在不解体复制体的情况下被动态招募并参与其中。
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