Perktold K, Peter R O, Resch M, Langs G
Institute of Mathematics, Technical University Graz, Austria.
J Biomed Eng. 1991 Nov;13(6):507-15. doi: 10.1016/0141-5425(91)90100-l.
Flow and stress patterns in human carotid artery bifurcation models, which differ in the bifurcation angle, are analysed numerically under physiologically relevant flow conditions. The governing Navier-Stokes equations describing pulsatile, three-dimensional flow of an incompressible non-Newtonian fluid are approximated using a pressure correction finite element method, which has been developed recently. The non-Newtonian behaviour of blood is modelled using Casson's relation, based on measured dynamic viscosity. The study concentrates on flow and stress characteristics in the carotid sinus. The results show that the complex flow in the sinus is affected by the angle variation. The magnitude of reversed flow, the extension of the recirculation zone in the outer sinus region and the duration of flow separation during the pulse cycle as well as the resulting wall shear stress are clearly different in the small angle and in the large angle bifurcation. The haemodynamic phenomena, which are important in atherogenesis, are more pronounced in the large angle bifurcation.
在生理相关流动条件下，对具有不同分叉角度的人体颈动脉分叉模型中的流动和应力模式进行了数值分析。使用最近开发的压力修正有限元方法，对描述不可压缩非牛顿流体的脉动三维流动的控制纳维 - 斯托克斯方程进行了近似。基于测量的动态粘度，使用卡森关系对血液的非牛顿行为进行建模。该研究集中于颈动脉窦中的流动和应力特性。结果表明，窦内的复杂流动受角度变化的影响。在小角度和大角度分叉中，反向流动的大小、外窦区域再循环区的范围、脉冲周期内流动分离的持续时间以及由此产生的壁面剪应力明显不同。在动脉粥样硬化形成中重要的血流动力学现象在大角度分叉中更为明显。
