Sato Takeo, Kokuba Yukihito, Koizumi Wasaburo, Ozawa Heita, Nakamura Takatoshi, Ihara Atsushi, Ootani Yoshimasa, Watanabe Masahiko
Department of Surgery , Kitasato University School of Medicine, Kanagawa, Japan.
Hepatogastroenterology. 2007 Jul-Aug;54(77):1391-3.
We performed preoperative chemoradiotherapy in locally advanced cases of rectal cancer without distant metastasis. The methods for drug administration and irradiation were as follows: oral administration of S-1 at 80 mg/m2/day on days 1-5, 8-12, 22-26, and 29-33, with periods of 5 days on drug and 2 days off drug and intravascular administration of CPT-11 for 120 minutes on days 1, 8, 22, and 29, at doses of 60 mg/m2/day in Case 1 and 70 mg/m2/day in Case 2. The radiation dosage was a fractionated exposure of 1.8 Gy/day x 5 days/week for 5 weeks, for a total of 45 Gy. No major adverse events were observed in either case, and the treatment was performed as per the protocol. No postoperative complications were observed in either case. Both patients showed complete pathological remission with no evidence of tumor cells in the primary focus and no lymph node metastases. Preoperative chemoradiotherapy with a combination of S-1 and CPT-11 may be a new treatment for rectal cancer.
我们对无远处转移的局部晚期直肠癌病例进行了术前放化疗。给药和放疗方法如下：S-1在第1 - 5天、8 - 12天、22 - 26天以及29 - 33天口服，剂量为80mg/m²/天，服药5天，停药2天；CPT-11在第1天、8天、22天和29天静脉给药120分钟，病例1剂量为60mg/m²/天，病例2剂量为70mg/m²/天。放射剂量为每周5天，每天1.8Gy，分阶段照射5周，共45Gy。两例均未观察到严重不良事件，治疗按方案进行。两例均未观察到术后并发症。两名患者均显示完全病理缓解，原发灶无肿瘤细胞证据，无淋巴结转移。S-1与CPT-11联合的术前放化疗可能是直肠癌的一种新治疗方法。
