Ritschel W A, Vachharajani N N, Johnson R D, Hussain A S
Division of Pharmaceutics and Drug Delivery Systems, College of Pharmacy, University of Cincinnati Medical Center, OH.
Methods Find Exp Clin Pharmacol. 1991 Dec;13(10):697-702.
The pharmacokinetic parameters, total body clearance, apparent volume of distribution and the terminal elimination half-life of coumarin were correlated among six mammalian species. It was demonstrated that the total body clearance was highly related to the liver blood flow, liver weight and body weight. The apparent volume of distribution appeared to be related only to body weight. The elimination half-life, which is dependent upon both the apparent volume of distribution and total body clearance, was poorly correlated with all physiologic variables that were evaluated. Hence, it appears that only the primary pharmacokinetic parameters of coumarin display a definite interspecies relationship.
香豆素的药代动力学参数、总体清除率、表观分布容积和末端消除半衰期在六种哺乳动物物种之间具有相关性。结果表明，总体清除率与肝血流量、肝脏重量和体重高度相关。表观分布容积似乎仅与体重有关。消除半衰期取决于表观分布容积和总体清除率，与所有评估的生理变量相关性较差。因此，似乎只有香豆素的主要药代动力学参数显示出明确的种间关系。
