Dept of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Trends Cell Biol. 1997 Nov;7(11):442-6. doi: 10.1016/S0962-8924(97)01159-8.
Hedgehog (HH) proteins are an important class of secreted intercellular signals. The HH signal-transduction pathway is not fully understood, but a number of novel features have been elucidated recently. It is now clear that, during processing to generate an active signal, Drosophila HH proteins become covalently linked to cholesterol and are thereby largely tethered to the cell surface. HH signalling could therefore be affected by cholesterol metabolism. In addition, the pathway downstream of receptor binding involves a unique signalling complex containing the transcription factor CUBITUS INTERRUPTUS (CI), which becomes dissociated from microtubules in response to HH. This review discusses these new findings and their implications for HH signalling.
刺猬 (HH) 蛋白是一类重要的分泌性细胞间信号分子。HH 信号转导途径尚未完全阐明，但最近已经阐明了一些新的特征。现在很清楚，在产生活性信号的过程中，果蝇 HH 蛋白与胆固醇发生共价连接，从而被大量束缚在细胞膜表面。因此，HH 信号可能受到胆固醇代谢的影响。此外，受体结合下游的途径涉及一个包含转录因子 CUBITUS INTERRUPTUS (CI) 的独特信号复合物，该复合物在响应 HH 时与微管分离。这篇综述讨论了这些新发现及其对 HH 信号的影响。
