Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Exp Biol Med (Maywood). 2010 Apr;235(4):447-54. doi: 10.1258/ebm.2009.009303.
The developmental Hedgehog (Hh) protein family is known to be pivotal in many embryonic patterning events and the number of processes in which Hh plays an essential role is expanding persistently. Recently, it has become clear that the Hh pathway is not only active in the developing embryo but also in the adult organism. For example, Hh has been suggested to salvage ischemia-induced tissue damage although endogenous Hh might be deleterious during the early phase of myocardial ischemia-reperfusion. The current review provides an overview of the history of Hh biology and discusses some novel insights on Hh cell biology. Hh function in pathophysiology as well as recent findings concerning Hh signaling in ischemia models, especially in light of cardiovascular disease, is discussed in more detail and future perspectives are proposed.
发育中的 Hedgehog（Hh）蛋白家族在许多胚胎形态发生事件中起着关键作用，Hh 发挥重要作用的过程数量也在持续增加。最近，人们已经清楚地认识到，Hh 途径不仅在发育中的胚胎中活跃，而且在成年生物体内也活跃。例如，尽管内源性 Hh 在心肌缺血再灌注的早期阶段可能是有害的，但 Hh 被认为可以挽救缺血引起的组织损伤。本综述提供了 Hh 生物学的历史概述，并讨论了一些关于 Hh 细胞生物学的新见解。本文详细讨论了 Hh 在病理生理学中的功能，以及最近关于缺血模型中 Hh 信号的发现，特别是在心血管疾病方面，并提出了未来的展望。
