Trends Cell Biol. 1997 Dec;7(12):473-9. doi: 10.1016/S0962-8924(97)01167-7.
Natural killer (NK) cells employ an unconventional mode of recognition: they kill target cells that lack ligands for inhibitory NK cell receptors. Activation of NK cytotoxicity is tightly controlled by inhibitory receptors that recruit and activate the tyrosine phosphatase SHP-1 through the tyrosine-phosphorylated [I/V]xYxxL amino acid sequence in their cytoplasmic tail. This sequence motif, often referred to as an immunoreceptor tyrosine-based inhibitory motif (ITIM), is found in several other receptors that deliver similar negative signals in diverse types of cells. We suggest that this kind of regulation through inhibition is a widespread mechanism for the control of various cellular responses.
自然杀伤 (NK) 细胞采用一种非传统的识别模式：它们杀死缺乏抑制性 NK 细胞受体配体的靶细胞。NK 细胞毒性的激活受到抑制性受体的严格控制，这些受体通过其细胞质尾部中的酪氨酸磷酸化 [I/V]xYxxL 氨基酸序列募集并激活酪氨酸磷酸酶 SHP-1。这个序列基序，通常称为免疫受体酪氨酸基抑制基序 (ITIM)，存在于其他几种受体中，这些受体在不同类型的细胞中传递类似的负信号。我们认为，这种通过抑制进行的调节是控制各种细胞反应的一种广泛机制。
