Trends Cell Biol. 1997 Dec;7(12):485-92. doi: 10.1016/S0962-8924(97)01162-8.
In Xenopus and Drosophila oocytes, a number of maternally synthesized RNAs encoding molecules that act in formation and patterning of embryonic tissues are localized to the vegetal and posterior poles, respectively. In Drosophila, and probably in Xenopus, localization of their RNAs within the oocyte generates the regionalized distributions of these molecules in the early embryo that are required for proper development. Studies described here have begun to reveal components of the cellular machinery that effects RNA localization. While specific aspects of localization differ among RNAs, similarities between pathways used by Xenopus and Drosophila suggest that common themes have been conserved among localization mechanisms.
在非洲爪蟾和果蝇的卵母细胞中，许多由母体合成的 RNA 编码的分子分别定位于植物极和后极，这些分子在胚胎组织的形成和模式形成中起作用。在果蝇中，可能在非洲爪蟾中，这些 RNA 在卵母细胞中的定位产生了这些分子在早期胚胎中的区域分布，这对于正常发育是必需的。本文所描述的研究已经开始揭示影响 RNA 定位的细胞机制的组成部分。虽然不同 RNA 的定位方式存在具体差异，但非洲爪蟾和果蝇所使用的途径之间的相似性表明，定位机制中存在共同的主题。
