Koh Hyongjong, Chung Jongkyeong
National Creative Research Initiatives Center for Cell Growth Regulation and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Republic of Korea.
Biochem Biophys Res Commun. 2007 Nov 3;362(4):789-92. doi: 10.1016/j.bbrc.2007.08.016. Epub 2007 Aug 10.
AMP-activated protein kinase (AMPK) is known as an important cellular energy sensor, but its in vivo role has not been fully understood. Recent studies provided surprising results that AMPK regulates cell polarity and mitosis under the control of tumour suppressor LKB1. Moreover, these newly found in vivo functions of AMPK are regulated by energy status in a cell autonomous manner. These findings provide novel insights into the physiological function of AMPK and the treatment of AMPK-related diseases such as cancer and diabetes.
AMP激活的蛋白激酶（AMPK）被认为是一种重要的细胞能量传感器，但其在体内的作用尚未完全明确。最近的研究给出了惊人的结果，即AMPK在肿瘤抑制因子LKB1的控制下调节细胞极性和有丝分裂。此外，AMPK这些新发现的体内功能以细胞自主的方式受能量状态调控。这些发现为AMPK的生理功能以及癌症和糖尿病等与AMPK相关疾病的治疗提供了新的见解。
