Almeida Ricardo, Tyers Mike
Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Dev Cell. 2009 Jul;17(1):3-4. doi: 10.1016/j.devcel.2009.07.006.
The phenomenon of cell size homeostasis, whereby cells coordinate growth and division to maintain a uniform cell size, has been an outstanding issue in cell biology for many decades. Two recent studies in Nature in fission yeast demonstrate that a gradient of the polarity factor Pom1 is a sensor of cell length that determines the onset of Cdc2 activation and mitosis.
细胞大小稳态现象，即细胞协调生长与分裂以维持统一的细胞大小，数十年来一直是细胞生物学中的一个突出问题。《自然》杂志最近发表的两项关于裂殖酵母的研究表明，极性因子Pom1的梯度是细胞长度的传感器，它决定了Cdc2激活和有丝分裂的起始。
