Rico H, Robledo A, Crabranes J A, Lopez-Bran E, Hernandez E R
Departamento de Medicina, Universidad de Alcalá de Henares, Madrid, España.
Miner Electrolyte Metab. 1991;17(1):12-5.
This report was motivated by the finding that calciotropic hormones, except parathormone (PTH), do not show any response to 1a(OH)D3 therapy in psoriatic patients. These showed high basal whole PTH levels (127 +/- 38 pg/ml) which declined to 45 +/- 15 pg/ml after treatment (p less than 0.001) but did not correlate to calcemia values. Basal calcemia and calciuria were normal and rose with treatment (p less than 0.001 for both). Basal calcitonin and 25(OH)D3 were normal and did not change with treatment nor correlate to changes in calcemia. Due to the effect of 1-hydroxyvitamin D and calcemia on calcitonin and 25(OH)D, the lack of changes in the latter suggests a calciotropic hormone imbalance in psoriasis, which may be an etiologic factor in this entity.
本报告的起因是发现除甲状旁腺激素（PTH）外，促钙激素在银屑病患者中对1α（OH）D3治疗无任何反应。这些患者的基础全段PTH水平较高（127±38 pg/ml），治疗后降至45±15 pg/ml（p<0.001），但与血钙值无关。基础血钙和尿钙正常，治疗后升高（两者均p<0.001）。基础降钙素和25（OH）D3正常，治疗后无变化，也与血钙变化无关。由于1-羟维生素D和血钙对降钙素及25（OH）D的影响，后者无变化提示银屑病中促钙激素失衡，这可能是该疾病的一个病因。
