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住院服务专科对非ST段抬高型急性冠状动脉综合征患者护理过程及结局的影响。

Influence of inpatient service specialty on care processes and outcomes for patients with non ST-segment elevation acute coronary syndromes.

作者信息

Roe Matthew T, Chen Anita Y, Mehta Rajendra H, Li Yun, Brindis Ralph G, Smith Sidney C, Rumsfeld John S, Gibler W Brian, Ohman E Magnus, Peterson Eric D

机构信息

Duke University Medical Center and Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA.

出版信息

Circulation. 2007 Sep 4;116(10):1153-61. doi: 10.1161/CIRCULATIONAHA.107.697003. Epub 2007 Aug 20.

Abstract

BACKGROUND

Since the broad dissemination of practice guidelines, the association of specialty care with the treatment of patients with acute coronary syndromes has not been studied.

METHODS AND RESULTS

We evaluated 55 994 patients with non-ST-segment elevation acute coronary syndromes (ischemic ST-segment changes and/or positive cardiac markers) included in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines) Quality Improvement Initiative from January 2001 through September 2003 at 301 tertiary US hospitals with full revascularization capabilities. We compared baseline characteristics, the use of American College of Cardiology/American Heart Association guidelines class I recommendations, and in-hospital outcomes by the specialty of the primary in-patient service (cardiology versus noncardiology). A total of 35 374 patients (63.2%) were primarily cared for by a cardiology service, and these patients had lower-risk clinical characteristics, but they more commonly received acute (</=24 hours) medications, invasive cardiac procedures, and discharge medications and lifestyle interventions. Acute care processes were improved when care was provided by a cardiology service regardless of the propensity to receive cardiology care. The adjusted risk of in-hospital mortality was lower with care provided by a cardiology service (adjusted odds ratio 0.80, 95% confidence interval 0.73 to 0.88), and adjustment for differences in the use of acute medications and invasive procedures partially attenuated this mortality difference (adjusted odds ratio 0.92, 95% confidence interval 0.83 to 1.02).

CONCLUSIONS

Non-ST-segment elevation acute coronary syndrome patients primarily cared for by a cardiology inpatient service more commonly received evidence-based treatments and had a lower risk of mortality, but these patients had lower-risk clinical characteristics. Results from the present analysis highlight the difficulties with accurately determining how specialty care is associated with treatment patterns and clinical outcomes for patients with acute coronary syndromes. Novel methodologies for evaluating the influence of specialty care for these patients need to be developed and applied to future studies.

摘要

背景

自实践指南广泛传播以来,专科护理与急性冠状动脉综合征患者治疗之间的关联尚未得到研究。

方法与结果

我们评估了2001年1月至2003年9月期间纳入CRUSADE(不稳定型心绞痛患者快速风险分层能否通过早期实施ACC/AHA指南抑制不良结局)质量改进计划的55994例非ST段抬高型急性冠状动脉综合征患者(缺血性ST段改变和/或心脏标志物阳性),这些患者来自美国301家具备完全血运重建能力的三级医院。我们比较了基线特征、美国心脏病学会/美国心脏协会I类推荐的使用情况,以及根据主要住院科室(心脏病学与非心脏病学)专科划分的院内结局。共有35374例患者(63.2%)主要由心脏病学科室护理,这些患者具有较低风险的临床特征,但他们更常接受急性(≤24小时)药物治疗、侵入性心脏手术、出院药物治疗和生活方式干预。无论接受心脏病学护理的倾向如何,由心脏病学科室提供护理时,急性护理流程均得到改善。由心脏病学科室提供护理时,院内死亡的调整风险较低(调整比值比0.80,95%置信区间0.73至0.88),对急性药物治疗和侵入性手术使用差异进行调整后,这种死亡率差异部分减弱(调整比值比0.92,95%置信区间0.83至1.02)。

结论

主要由心脏病学住院科室护理的非ST段抬高型急性冠状动脉综合征患者更常接受循证治疗,且死亡风险较低,但这些患者具有较低风险的临床特征。本分析结果凸显了准确确定专科护理与急性冠状动脉综合征患者治疗模式和临床结局之间关联的困难。需要开发新的方法来评估专科护理对这些患者的影响,并应用于未来的研究。

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