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Strong activation of PAR-2 receptors: a common trigger for the development of gastrointestinal adenocarcinomas?

作者信息

Olbe Lars

机构信息

Department of Gastrosurgical Research, Sahlgrenska University Hospital, Gothenburg, Sweden.

出版信息

Scand J Gastroenterol. 2007 Sep;42(9):1133-7. doi: 10.1080/00365520601175983.

DOI:10.1080/00365520601175983
PMID:17710682
Abstract

Helicobacter pylori infection is considered to be an important factor in the development of gastric cancer, while duodenogastroesophageal reflux is claimed to be the main cause of development of esophageal adenocarcinoma. A pronounced activation of PAR-2 receptors may be a common denominator in triggering the development of these cancers, and possibly pancreatic and colonic cancers as well. Evidence supporting such a concept is presented.

摘要

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Strong activation of PAR-2 receptors: a common trigger for the development of gastrointestinal adenocarcinomas?
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引用本文的文献

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PAR-2 promotes invasion and migration of esophageal cancer cells by activating MEK/ERK and PI3K/Akt signaling pathway.PAR-2通过激活MEK/ERK和PI3K/Akt信号通路促进食管癌细胞的侵袭和迁移。
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