Jeznach-Steinhagen Anna, Słotwiński Robert, Szczygieł Bruno
Zakład Zywienia Czówieka, Wydział Nauki o Zdrowiu, Akademia Medyczna w Warszawie, 01-445 Warszawa.
Rocz Panstw Zakl Hig. 2007;58(1):83-8.
Protein-energy malnutrition with muscle wasting occurs in a large proportion of patients with chronic renal failure and is, in addition to atherosclerosis, a strong risk factor for cardiovascular mortality in dialysis patients. There is evidence that a chronic inflammation with activation of C-reactive protein and proinfalammatory cytokines is associated with increased oxidative stress and endothelial dysfunction. Strong relations between malnutrition, inflammation and atherosclerosis in dialysis patients suggest the presence of a MIA (malnutrition, inflammation and atherosclerosis) syndrome, which is associated with high mortality rate. Thus, it could be speculated that suppression of the vicious cycle of malnutrition, inflammation and atherosclerosis would improve survival in dialysis patients.
蛋白质能量营养不良伴肌肉萎缩在很大比例的慢性肾衰竭患者中出现，并且除动脉粥样硬化外，还是透析患者心血管死亡的一个重要危险因素。有证据表明，C反应蛋白和促炎细胞因子激活所导致的慢性炎症与氧化应激增加及内皮功能障碍有关。透析患者中营养不良、炎症与动脉粥样硬化之间的密切关系提示存在一种营养不良、炎症和动脉粥样硬化（MIA）综合征，该综合征与高死亡率相关。因此，可以推测抑制营养不良、炎症和动脉粥样硬化的恶性循环将改善透析患者的生存率。
