Voellmy C, Speiser P, Soliva M
J Pharm Sci. 1977 May;66(5):631-4. doi: 10.1002/jps.2600660506.
A new method for the microencapsulation of solids is described. It is based on the polycondensation of amphiphilic and, thus, tensioactive precondensates on a melamine-formaldehyde base on the surface of suspended particles during spray drying. A film-forming agent, preferably one that reacts chemically with the resin, is indispensable for spray drying and also for the formation of an efficient membrane around the drug particles. The resulting microcapsules are essentially spherical and have, after appropriate curing, a sustained-release effect in vitro. The factors that most influence the formation and properties of the microcapsules are the composition (qualitative and quantitative), pH, and viscosity of the suspension.
描述了一种固体微囊化的新方法。它基于两亲性且因此具有表面活性的预缩合物在喷雾干燥过程中于悬浮颗粒表面的三聚氰胺 - 甲醛基体上进行缩聚反应。成膜剂，优选与树脂发生化学反应的成膜剂，对于喷雾干燥以及在药物颗粒周围形成高效膜而言是必不可少的。所得微囊基本上是球形的，经过适当固化后在体外具有缓释效果。对微囊形成和性质影响最大的因素是悬浮液的组成（定性和定量）、pH值和粘度。
