p53、Bcl-2和Ki-67在癌前宫颈病变及宫颈癌中的作用。
The role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical cancer.
作者信息
Türkçüoğlu I, Tezcan S, Kaygusuz G, Atabekoğlu C Somer, Ortaç F, Güngör M, Kankaya D, Sertçelik A
机构信息
Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey.
出版信息
Eur J Gynaecol Oncol. 2007;28(4):290-3.
PURPOSE
The aim of this study was to determine the role of p53, Bcl-2 and Ki-67 expression in the carcinogenesis of cervical carcinoma and aggressiveness of cervical intraepithelial neoplasia (CIN).
METHODS
The pathology specimens of 63 patients with a diagnosis of normal squamous epithelium (22 cases), CIN I (14), CIN II (5), CIN III (8) and squamous cell carcinoma (14) were evaluated immunohistochemically for the expression of p53, Bcl-2 and Ki-67 in paraffin sections.
RESULTS
The expression of p53 and Ki-67 increased proportionally to the grade of CIN and cervical cancer, but only the increase of p53 expression was statistically significant (p = 0.002). There was no significant correlation between Bcl-2 expression and premalignant and malignant cervical lesions.
CONCLUSION
p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions.
目的
本研究旨在确定p53、Bcl-2和Ki-67表达在宫颈癌发生及宫颈上皮内瘤变（CIN）侵袭性中的作用。
方法
对63例诊断为正常鳞状上皮（22例）、CIN I（14例）、CIN II（5例）、CIN III（8例）和鳞状细胞癌（14例）患者的病理标本进行石蜡切片免疫组织化学评估，检测p53、Bcl-2和Ki-67的表达。
结果
p53和Ki-67的表达随CIN分级及宫颈癌分级的升高而增加，但只有p53表达的增加具有统计学意义（p = 0.002）。Bcl-2表达与宫颈的癌前病变及恶性病变之间无显著相关性。
结论
p53表达可能在宫颈鳞状细胞癌的发生中起作用，而Bcl-2表达则无此作用。Ki-67表达不能用于确定CIN病变的侵袭性。
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