Elliott John O, Jacobson Mercedes P, Haneef Zulfi
The Ohio State University, Department of Neurology, 430 Means Hall, 1654 Upham Drive, Columbus, OH 43210, United States.
Epilepsy Res. 2007 Sep;76(2-3):113-23. doi: 10.1016/j.eplepsyres.2007.07.005. Epub 2007 Aug 21.
Epidemiological studies have found the risk for heart disease and stroke are increased in persons with epilepsy. Anti-epileptic drugs (AEDs) have varying effects on serum lipids and homocysteine-an independent risk factor for coronary disease. The prevalence of cardiovascular risk factors (high cholesterol, hypertension, diabetes, obesity and smoking) and homocysteine were investigated in a multiethnic epilepsy population. Data included demographics, clinical factors, lab assessments and supplementation patterns. Mean age was 45 years (71 males and 94 females)-75 were African American, 27 Latino and 60 Caucasian. Fifty-two percent of participants had two or more cardiovascular risk factors when compared with rates for the general population of 28%. The Framingham risk score (FRS) assessment was also used to compare risk levels. Twenty-nine percent of men and 1% of women had a FRS indicating >5% level of risk, only 7% had a FRS>10%. Cardiovascular screening and primary preventative recommendations based on the American Heart Association and supplementation should be suggested for the adult epilepsy population when appropriate.
流行病学研究发现，癫痫患者患心脏病和中风的风险会增加。抗癫痫药物（AEDs）对血脂和同型半胱氨酸（冠心病的一个独立风险因素）有不同影响。在一个多种族癫痫人群中，对心血管危险因素（高胆固醇、高血压、糖尿病、肥胖和吸烟）和同型半胱氨酸的患病率进行了调查。数据包括人口统计学、临床因素、实验室评估和补充模式。平均年龄为45岁（71名男性和94名女性）——75人为非裔美国人，27人为拉丁裔，60人为白种人。与普通人群28%的患病率相比，52%的参与者有两种或更多心血管危险因素。还使用弗雷明汉风险评分（FRS）评估来比较风险水平。29%的男性和1%的女性FRS表明风险水平>5%，只有7%的人FRS>10%。应在适当的时候为成年癫痫人群建议基于美国心脏协会的心血管筛查和一级预防建议以及补充措施。
