Zhou Li-Xue, Zhu Jun, Ding Hong, Jia Cai-Xia, Xue Shu-Juan, Pan Rui-Ke
Department of Gynecology and Obstetrics, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2007 Aug;27(8):1227-9.
To assess the effect of different schemes of premenopausal tamoxifen therapy on the endometrium.
Totally 109 normal premenopausal women positive for high-risk factors of breast cancer were divided into two groups, namely periodic and consecutive tamoxifen treatment groups. Endometrial thickness as examined by vaginal sonography was assessed in relation to duration of tamoxifen use and time from discontinuation of the drug.
After one year of tamoxifen use, the mean endometrial thickness in periodic treatment group was 6.5-/+1.4 mm, and 10.2-/+2.0 mm in consecutive treatment group. Endometrial thickness increased with the duration of tamoxifen use at the rate of 0.51 mm/year in the periodic treatment group, and 0.73 mm/year in consecutive treatment group. After discontinuation of tamoxifen, the endometrial thickness in the former group decreased by 1.29 mm/year, and by 1.33 mm/year in the latter.
Endometrial hyperplasia is obviously milder in premenopausal women receiving periodic tamoxifen treatment who are at risk for breast cancer than that in women with consecutive treatment. After discontinuation of the drug, the endometrial thickness decreases at a roughly equal slow rate in the two groups.
评估绝经前他莫昔芬不同治疗方案对子宫内膜的影响。
将109例乳腺癌高危因素阳性的绝经前正常女性分为两组，即他莫昔芬周期治疗组和连续治疗组。通过阴道超声检查评估子宫内膜厚度，并分析其与他莫昔芬使用时间及停药时间的关系。
使用他莫昔芬一年后，周期治疗组的平均子宫内膜厚度为6.5±1.4mm，连续治疗组为10.2±2.0mm。在周期治疗组中，子宫内膜厚度随他莫昔芬使用时间以每年0.51mm的速度增加，在连续治疗组中为每年0.73mm。停药后，前一组的子宫内膜厚度以每年1.29mm的速度下降，后一组为每年1.33mm。
对于有乳腺癌风险的绝经前女性，接受他莫昔芬周期治疗时子宫内膜增生明显轻于连续治疗的女性。停药后，两组子宫内膜厚度以大致相同的缓慢速度下降。
