Puche R C, Locatto M E, Ferretti J L, Fernandez M C, Orsatti M B, Valenti J L
Calcif Tissue Res. 1976 Apr 20(2):105-19. doi: 10.1007/BF02546401.
The effects of the long term ingestion of Solanum Glaucophyllum leaves (SG) by the rat was investigated in two series of experiments; the animals were fed a normal (for 8 weeks) or a low Ca diet (for 5 weeks). With both diets, the intestinal absorption of Ca was increased and the endogenous fecal Ca excretion was decreased by SG treatment. Added to a normal Ca diet, SG increased the urinary excretion of Ca, Mg and P and reduced the excretion of hydroxyproline and pyrophosphate. At the histological level, SG induced a higher rate of bone tissue synthesis on trabecular and endosteal surfaces. The bone content of hydroxyproline and citrate increased significantly. The total alkaline phosphatase activity of plasma decreased as a function of SG intake due to a decreased in the activity of the intestinal isoenzyme, which was not compensated by the increase in the bone isoenzyme activity. The Mg absorption was decreased by SG inducing lower Mg balances and lower plasma Mg levels. Added to a low Ca diet, SG increased the severity of the secondary hyperparathyroidism induced by the diet. The urinary excretion of hydroxyproline and the plasma alkaline phosphatase activity (both isoenzymes) were significantly increased. The Na and K content of bone decreased as a function of SG intake. 45Ca kinetic experiments revealed that SG increased the rate of Ca resorption and the rate constant of the fast exchangeable Ca pool, in both diets.
在两个系列的实验中研究了大鼠长期摄入青刺茄叶（SG）的影响；动物分别喂食正常饮食（8周）或低钙饮食（5周）。无论哪种饮食，SG处理均可增加钙的肠道吸收并减少内源性粪便钙排泄。添加到正常钙饮食中，SG可增加钙、镁和磷的尿排泄，并减少羟脯氨酸和焦磷酸的排泄。在组织学水平上，SG可诱导小梁和骨内膜表面的骨组织合成率更高。羟脯氨酸和柠檬酸盐的骨含量显著增加。由于肠道同工酶活性降低，血浆总碱性磷酸酶活性随SG摄入量的增加而降低，且未被骨同工酶活性的增加所补偿。SG可降低镁的吸收，导致镁平衡降低和血浆镁水平降低。添加到低钙饮食中，SG会增加饮食诱导的继发性甲状旁腺功能亢进的严重程度。羟脯氨酸的尿排泄和血浆碱性磷酸酶活性（两种同工酶）均显著增加。骨中的钠和钾含量随SG摄入量的增加而降低。45Ca动力学实验表明，在两种饮食中，SG均可增加钙的再吸收率和快速可交换钙池的速率常数。
