Lieving Lori M, Cherek Don R, Lane Scott D, Tcheremissine Oleg V, Nouvion Sylvain O
University of Texas-Houston, Health Science Center, USA.
J Psychopharmacol. 2008 Mar;22(2):144-52. doi: 10.1177/0269881107078489. Epub 2007 Aug 22.
Experimental and clinical studies have supported a relationship between gamma-aminobutyric acid (GABA) and aggressive behavior in non-humans and humans. Tiagabine is a GABA uptake inhibitor that has been shown to produce acute behavioral effects in animals. In addition, tiagabine has been shown to decrease aggression in agitated patients when administered chronically. The present study was designed to investigate the effects of acute administration of tiagabine on aggressive responding on a laboratory task in adult humans. Ten adult males participated in experimental sessions on the Point Subtraction Aggression Paradigm (PSAP), which provided subjects with aggressive, escape, and monetary-reinforced response options. All subjects received four acute oral doses of Tiagabine (4, 8, 12 and 16 mg) separated by placebo sessions. Tiagabine decreased aggression at doses that either did not affect, or affected to a lesser extent, monetary-reinforced responding. The results are consistent with some prior research using the PSAP showing a possible unique role for GABA in the regulation of human aggression. A possible behavioral mechanism for the rate-decreasing effects on aggressive responding produced in the present study is that tiagabine may modify aggressive responding by suppressing reactions to aversive stimuli.
实验和临床研究证实了γ-氨基丁酸（GABA）与非人类及人类攻击行为之间的关联。噻加宾是一种GABA摄取抑制剂，已被证明可在动物身上产生急性行为效应。此外，长期给药时，噻加宾已被证明可减少躁动患者的攻击行为。本研究旨在调查急性给予噻加宾对成年人类实验室任务中攻击反应的影响。十名成年男性参与了基于点减法攻击范式（PSAP）的实验环节，该范式为受试者提供了攻击、逃避和金钱强化反应选项。所有受试者在安慰剂疗程间隔下接受了四次急性口服剂量的噻加宾（4、8、12和16毫克）。噻加宾在不影响或较小程度影响金钱强化反应的剂量下降低了攻击行为。这些结果与之前一些使用PSAP的研究一致，表明GABA在调节人类攻击行为中可能具有独特作用。本研究中对攻击反应产生速率降低效应的一种可能行为机制是，噻加宾可能通过抑制对厌恶刺激的反应来改变攻击反应。
