甲型和乙型流感病毒中，非结构NS1蛋白对磷脂酰肌醇3激酶信号传导的激活作用并不保守。
Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.
作者信息
Ehrhardt Christina, Wolff Thorsten, Ludwig Stephan
机构信息
Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von Esmarch-Strasse 56, D-48149 Muenster, Germany.
出版信息
J Virol. 2007 Nov;81(21):12097-100. doi: 10.1128/JVI.01216-07. Epub 2007 Aug 22.
Abstract
Recently it has been shown by several laboratories that the influenza A virus nonstructural protein 1 (A/NS1) binds and activates phosphatidylinositol 3-kinase (PI3K). This function of the protein is likely to prevent premature apoptosis induction during viral propagation. Here we show that the B/NS1 protein completely lacks the capacity to induce PI3K signaling. Thus, PI3K activation is another unique function of A/NS1 that is different from the action of its influenza B virus counterpart.
摘要
最近，几个实验室已表明，甲型流感病毒非结构蛋白1（A/NS1）可结合并激活磷脂酰肌醇3激酶（PI3K）。该蛋白的这一功能可能会在病毒传播过程中防止过早诱导细胞凋亡。在此我们表明，B/NS1蛋白完全缺乏诱导PI3K信号传导的能力。因此，PI3K激活是A/NS1的另一个独特功能，与其乙型流感病毒对应物的作用不同。
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