Plengvidhya Nattachet, Leelawatana Rattana, Pratipanawatr Thongchai, Deerochanawong Chaicharn, Krittiyawong Sirinate, Bunnag Pongamorn, Kosachunhanun Nattapong, Suwanwalaikorn Sompongse, Benjasuratwong Yupin, Chetthakul Thanya, Ngarmukos Chadpraorn, Vannasaeng Sathit, Mongkolsomlit Sirima, Komoltri Chulaluk, Rawdaree Petch
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand.
J Med Assoc Thai. 2006 Aug;89 Suppl 1:S49-53.
To determine the prevalence of stroke and its risk factors in Thai diabetic patients who attended the diabetes clinics of university and tertiary-care hospitals.
A cross-sectional, multi-center hospital-based diabetes registry was carried out at diabetes clinics of 11 university and tertiary-care hospitals. Demographic data, clinical characteristics, common drugs used and laboratory parameters were analyzed for prevalence and risk factors associated with stroke.
The prevalence of stroke in the patients studied was 3.5%. Most of the patients were type 2 diabetes and had ischemic stroke. One of the risk factors associated with stroke was age greater than 60 years, and the risk appeared to be highest if the patients' age was greater than 70 years (adjust OR = 3.29, p = 0.012). Other risk factors included male sex, systolic blood pressure of > or =140 mmHg, use of oral hypoglycemic agents, lipid lowering agents and aspirin. There was no association between stroke and duration of diabetes, occupation, educational level, BMI, smoking, alcohol drinking, diastolic blood pressure, use of antihypertensive drugs or insulin, glycemic control, lipid profiles and kidney function.
Ischemic stroke was common among Thai patients with diabetes especially in the elderly. The present result emphasizes the relationship between level of systolic blood pressure and the occurrence of stroke. Optimal blood pressure control should be underscored in caring for diabetic patients.
确定在大学及三级护理医院糖尿病门诊就诊的泰国糖尿病患者中中风及其危险因素的患病率。
在11所大学及三级护理医院的糖尿病门诊开展了一项基于医院的横断面多中心糖尿病登记研究。分析了人口统计学数据、临床特征、常用药物及实验室参数，以了解与中风相关的患病率及危险因素。
所研究患者中中风的患病率为3.5%。大多数患者为2型糖尿病且患有缺血性中风。与中风相关的危险因素之一是年龄大于60岁，若患者年龄大于70岁，风险似乎最高（校正比值比=3.29，p=0.012）。其他危险因素包括男性、收缩压≥140 mmHg、使用口服降糖药、降脂药和阿司匹林。中风与糖尿病病程、职业、教育程度、体重指数、吸烟、饮酒、舒张压、使用抗高血压药物或胰岛素、血糖控制、血脂谱及肾功能之间无关联。
缺血性中风在泰国糖尿病患者中很常见，尤其是老年人。目前的结果强调了收缩压水平与中风发生之间的关系。在糖尿病患者护理中应强调最佳血压控制。
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