[Visceral morphofunctional changes in guinea-pigs during long-term administration of antituberculous agents].

Antituberculous drugs (ATD) can adversely affect the kidney and liver. Visceral morphological and histochemical changes were studied in guinea-pigs long receiving a combination of 2 or 5 ATDs. The use of ATDs caused changes at all levels (organ, tissue, and cell). The liver exhibited a pattern of microvesicular steatosis and the kidneys showed hyaline dropwise degeneration. The activity of NADN-DH, NADRH-GH, lactate dehydrogenase, glucose-6-phosphate dehydrogenase lowered in the liver and kidneys, so did the activity of acid phosphatase in the alveolar macrophages. More pronounced changes were detected after the use of 5 ATDs.