Taweevisit Mana
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
J Med Assoc Thai. 2006 Sep;89 Suppl 3:S69-73.
Resembling other neoplasms, the colorectal carcinogenesis is still a riddle in various aspects. Mast cells, a type of inflammatory cells, may play a role in colonic cancer pathogenesis. It has recently been found to have an essential function in tumor development and its immunologic response.
To evaluate the relation between mast cell number and biology of colorectal adenocarcinoma.
The author collected 162 cases, diagnosed as primary adenocarcinoma of the colon at the King Chulalongkorn Memorial Hospital, between 2002 and 2003, for evaluating the role of mast cells in colorectal cancers. The hematoxylin and eosin stained sections were reviewed and classified into the tumor differentiation or grading, depth of tumor invasion, and status of regional lymph node metastasis, according to the World Heath Organization's (WHO) criteria. Mast cell number within and around the tumor was counted on the 0.1% toluidine blue stained sections. F-test was used to correlate between the mast cell quantity and aforementioned tumor parameters.
The tumor differentiation consisted of grade 1 (34%), grade 2 (52%) and grade 3 (14%), with a mean of mast cell number of23, 32 and 40 cells/mm2, respectively. In addition, mast cell quantity in poorly differentiated tumors was significantly higher than those in well differentiated form (p = 0. 03). Therefore, mast cell number was not correlated with tumor depth (p = 0.28) and nodal status (p = 0. 75).
This observation might indicate that mast cell function has a role in colorectal pathogenesis.
与其他肿瘤相似，结直肠癌的发生在各个方面仍是一个谜。肥大细胞作为一种炎症细胞，可能在结肠癌的发病机制中发挥作用。最近发现它在肿瘤发展及其免疫反应中具有重要功能。
评估肥大细胞数量与结直肠癌生物学行为之间的关系。
作者收集了2002年至2003年间在朱拉隆功国王纪念医院被诊断为原发性结肠癌的162例病例，以评估肥大细胞在结直肠癌中的作用。根据世界卫生组织（WHO）的标准，对苏木精和伊红染色切片进行复查，并分类为肿瘤分化或分级、肿瘤浸润深度和区域淋巴结转移状态。在0.1%甲苯胺蓝染色切片上计数肿瘤内和肿瘤周围的肥大细胞数量。采用F检验来关联肥大细胞数量与上述肿瘤参数。
肿瘤分化包括1级（34%）、2级（52%）和3级（14%），肥大细胞数量的平均值分别为23、32和40个细胞/mm²。此外，低分化肿瘤中的肥大细胞数量明显高于高分化肿瘤（p = 0.03）。因此，肥大细胞数量与肿瘤深度（p = 0.28）和淋巴结状态（p = 0.75）无关。
这一观察结果可能表明肥大细胞功能在结直肠癌发病机制中起作用。
