我该留下还是离开：突触处的Wnt信号

Should I stay or should I go: Wnt signals at the synapse.

作者信息

Davis Elizabeth, Ghosh Anirvan

机构信息

Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA.

出版信息

Cell. 2007 Aug 24;130(4):593-6. doi: 10.1016/j.cell.2007.08.007.

DOI:10.1016/j.cell.2007.08.007

PMID:17719537

Abstract

Several extracellular factors, including Wnt proteins, have been reported to induce synapse formation. In this issue, Klassen and Shen (2007) report that Wnt proteins can also act as antisynaptogenic signals to prevent synapse formation in certain parts of the worm Caenorhabditis elegans. The differential response of axon populations to local Wnt proteins may contribute to the patterning of synaptic connections.

摘要

据报道，包括Wnt蛋白在内的几种细胞外因子可诱导突触形成。在本期中，克拉森和沈（2007年）报道，Wnt蛋白也可作为抗突触生成信号，阻止秀丽隐杆线虫特定部位的突触形成。轴突群体对局部Wnt蛋白的不同反应可能有助于突触连接的模式形成。