Silhankova Marie, Korswagen Hendrik C
Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Curr Opin Genet Dev. 2007 Aug;17(4):320-5. doi: 10.1016/j.gde.2007.05.007. Epub 2007 Jul 20.
Migrating neuronal cells are directed to their final positions by an array of guidance cues. It has been shown that guidance molecules such as UNC-6/Netrin and SLT-1/Slit play a major role in controlling cell and axon migrations along the dorsal-ventral body axis. Much less is known, however, about the mechanisms that mediate migration along the anterior-posterior (AP) body axis. Recent research in Caenorhabditis elegans has uncovered an important role of the Wnt family of signalling molecules in controlling AP-directed neuronal cell migration and polarity. A common theme that emerges from these studies is that multiple Wnt proteins function in parallel as instructive cues or permissive signals to control neuronal patterning along this major body axis.
迁移的神经元细胞通过一系列引导线索被引导至其最终位置。研究表明，诸如UNC-6/Netrin和SLT-1/Slit等引导分子在控制细胞和轴突沿背腹体轴的迁移中起主要作用。然而，对于介导沿前后（AP）体轴迁移的机制知之甚少。秀丽隐杆线虫的最新研究揭示了Wnt信号分子家族在控制AP定向神经元细胞迁移和极性方面的重要作用。这些研究中出现的一个共同主题是，多种Wnt蛋白作为指导性线索或许可信号并行发挥作用，以控制沿这一主要体轴的神经元模式形成。
