Bansal P C, Monkhouse D C
J Pharm Sci. 1977 Jun;66(6):819-23. doi: 10.1002/jps.2600660620.
The hydrolytic degradation of pirbuterol was investigated under saturated oxygen conditions over a wide range of pH values and at different temperatures. Two of the five observed breakdown products were positively identified. The first-order decomposition rate appeared to depend on the rate constants of the four dissociated ionic species. The most stable region for the drug was pH 1-2, where the diprotonated molecule predominated; appropriate thermodynamic parameters were calculated.
在饱和氧条件下，于较宽的pH值范围及不同温度下研究了吡布特罗的水解降解情况。已明确鉴定出五个观察到的分解产物中的两个。一级分解速率似乎取决于四种解离离子形式的速率常数。该药物最稳定的区域是pH 1 - 2，此时双质子化分子占主导；计算了相应的热力学参数。
