A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.
作者信息
Ueda Jun-Ya, Togashi Takushi, Matukura Susumu, Nagai Aya, Nakashima Takuji, Komaki Hisayuki, Anzai Kozue, Harayama Shigeaki, Doi Takayuki, Takahashi Takashi, Natsume Tohru, Kisu Yasutomo, Goshima Naoki, Nomura Nobuo, Takagi Motoki, Shin-Ya Kazuo
机构信息
Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC), Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2007 Jul;60(7):459-62. doi: 10.1038/ja.2007.59.
A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.
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