A novel antiproliferative agent, phenylpyridineylbutenol, isolated from Streptomyces sp.
作者信息
Shin Choonshik, Lim Haeyoung, Moon Sangik, Kim Seunghyun, Yong Yeonjoong, Kim Bum-Joon, Lee Chul-Hoon, Lim Yoongho
机构信息
Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2006 Nov 1;16(21):5643-5. doi: 10.1016/j.bmcl.2006.08.015. Epub 2006 Aug 14.
PMID:16908144
Abstract
A novel compound showing antiproliferative effect was isolated from Streptomyces sp. Its structure was determined based on the interpretation of the NMR spectra, and its conformation was elucidated using molecular modeling and 2D NOESY. It was determined to be (E)-4-phenyl-3-(pyridine-2-yl)but-2-en-1-ol.
摘要
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