Angell Yu L, Burgess Kevin
Department of Chemistry, Texas A & M University, College Station, TX 77841, USA.
Chem Soc Rev. 2007 Oct;36(10):1674-89. doi: 10.1039/b701444a. Epub 2007 Jun 12.
This critical review concerns the impact of copper-mediated alkyne-azide cycloadditions on peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into peptide chains, to link peptides to other functionalities (e.g. carbohydrates, polymers, and labels), and as a basis for evolution of less peptidic compounds as pharmaceutical leads. It will be of interest to those studying this click reaction, peptidomimetic secondary structure and function, and to medicinal chemists.
这篇批判性综述关注铜介导的炔烃-叠氮环加成反应对拟肽研究的影响。它讨论了该反应如何用于将三唑插入肽链、将肽与其他功能基团（如碳水化合物、聚合物和标记物）连接，以及作为开发较少肽类化合物作为药物先导物的基础。对于研究这种点击反应、拟肽二级结构和功能的人员以及药物化学家来说，它将具有重要意义。
