McMillan Robert, Bussel James B, George James N, Lalla Deepa, Nichol Janet L
Scripps Research Institute, La Jolla, California, USA.
Am J Hematol. 2008 Feb;83(2):150-4. doi: 10.1002/ajh.20992.
Adult chronic immune thrombocytopenic purpura (ITP) is a disorder manifested by varying degrees of purpura and mucosal bleeding, rarely including intracranial hemorrhage. Therapy is aimed at increasing the patient's platelet count to safe levels and includes a wide variety of treatments. While the diagnosis, treatment, and prognosis of chronic ITP have been extensively discussed, the effect of ITP and its treatment on patient quality of life has not been evaluated in adults. In this study, the Short-Form 36 questionnaire was used to evaluate the health-related quality of life (HRQOL) of 73 adult ITP patients compared with that of the general U.S. population and of patients with six other relatively common chronic disorders. This study shows that the HRQOL of adult patients with ITP is significantly worse than that of the general U.S. population. It is also worse than that of patients with hypertension, arthritis, or cancer; similar to that of patients with diabetes; but better than that of patients with congestive heart failure or a missing or paralyzed limb. Future studies need to address the effects of treatment not only on the platelet count and bleeding but also on HRQOL.
成人慢性免疫性血小板减少性紫癜（ITP）是一种表现为不同程度紫癜和黏膜出血的疾病，极少包括颅内出血。治疗旨在将患者的血小板计数提高到安全水平，包括多种治疗方法。虽然慢性ITP的诊断、治疗和预后已得到广泛讨论，但ITP及其治疗对成人患者生活质量的影响尚未得到评估。在本研究中，使用简短健康调查问卷（Short-Form 36）来评估73例成年ITP患者的健康相关生活质量（HRQOL），并与美国普通人群以及其他六种相对常见的慢性疾病患者进行比较。本研究表明，成年ITP患者的HRQOL明显低于美国普通人群。它也低于高血压、关节炎或癌症患者；与糖尿病患者相似；但优于充血性心力衰竭或肢体缺失或瘫痪的患者。未来的研究不仅需要关注治疗对血小板计数和出血的影响，还需要关注对HRQOL的影响。
