Gómez-y-López Roberto Enrique, Hernández-Sierra Juan Francisco, Torres-Ruvalcaba Benito Antonio, Martínez-Puente Elsa, del Carmen Martínez-Garcia Maria
Hospital General de Zona con Medicina Familiar 1, IMSS, San Luis Potosí, SLP, México.
Gac Med Mex. 2007 May-Jun;143(3):189-92.
Asess the efficacy of nebulized salbutamol and dexamethasone compared with nebulized salbutamol, in patients with bronchiolitis.
A blinded clinical trial was performed with 49 patients between 1-18 months diagnosed with bronchiolitis with three days or less of disease evolution. Participant's parents signed an informed consent and patients did not receive prior medication. Patients were randomly assigned to two groups: nebulized salbutamol or salbutamol plus dexamethasone, which they received every four hours during twenty-four hours. We measured heart and respiratory rate; respiratory distress index, oxygen saturation, and Silverman Andersen scores.
No significant differences were found between groups for treatment response; but the frequency of hospital release at 24 hrs was significant among groups; 75 vs 96 % respectively (p = 0.04).
The administration of salbutamol plus dexamethasone is more effective in the control of respiratory distress in children with bronchiolitis compared with the use of salbutamol alone.
评估雾化吸入沙丁胺醇和地塞米松与单纯雾化吸入沙丁胺醇相比，对细支气管炎患者的疗效。
对49例年龄在1至18个月、诊断为细支气管炎且病程在3天及以内的患者进行了一项盲法临床试验。参与者的父母签署了知情同意书，患者未接受过先前的药物治疗。患者被随机分为两组：雾化吸入沙丁胺醇组或沙丁胺醇加地塞米松组，在24小时内每4小时接受一次治疗。我们测量了心率、呼吸频率、呼吸窘迫指数、血氧饱和度和西尔弗曼·安德森评分。
两组在治疗反应方面未发现显著差异；但两组在24小时时出院频率有显著差异，分别为75%和96%（p = 0.04）。
与单独使用沙丁胺醇相比，沙丁胺醇加地塞米松治疗对控制细支气管炎患儿的呼吸窘迫更有效。
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