Sun Jiantang, Zhu Ming-Qiang, Fu Kun, Lewinski Nastassja, Drezek Rebekah A
Department of Bioengineering , Rice University, Houston, TX 77005, USA.
Int J Nanomedicine. 2007;2(2):235-40.
In this paper, we report the use of lead sulfide quantum dot (PbS QD) bioconjugates as near infrared (NIR) contrast agents for targeted molecular imaging with expanded emission wavelengths beyond 1000 nm. The red-shifted emission band, coupled with the small particle size, which will facilitate clearance, both afford PbS QDs unique properties for noninvasive, high resolution in vivo NIR imaging applications. We have performed imaging experiments at the molecular level using surface-modified PbS NIR QDs, together with our lab-built NIR imaging system. This novel instrumentation and fluorescent contrast agent have enabled us to study the relatively unexplored NIR biomedical imaging spectral region of 900-1200 nm. Preliminary experimental results indicate that PbS-QD/antibody bioconjugates are promising candidates for targeted NIR molecular imaging and future in vivo NIR tissue imaging applications.
在本文中，我们报告了硫化铅量子点（PbS QD）生物共轭物作为近红外（NIR）造影剂用于靶向分子成像的情况，其发射波长扩展至1000 nm以上。红移发射带，再加上有利于清除的小粒径，这两者赋予了PbS量子点用于无创、高分辨率体内近红外成像应用的独特性质。我们使用表面修饰的PbS近红外量子点，结合我们实验室构建的近红外成像系统，在分子水平上进行了成像实验。这种新型仪器和荧光造影剂使我们能够研究900 - 1200 nm这个相对未被探索的近红外生物医学成像光谱区域。初步实验结果表明，PbS - QD/抗体生物共轭物是靶向近红外分子成像以及未来体内近红外组织成像应用的有前景的候选物。
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