Zimmer John P, Kim Sang-Wook, Ohnishi Shunsuke, Tanaka Eichii, Frangioni John V, Bawendi Moungi G
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA.
J Am Chem Soc. 2006 Mar 1;128(8):2526-7. doi: 10.1021/ja0579816.
We have developed a size series of unusually small, water-soluble (InAs)ZnSe (core)shell quantum dots (QDs) that emit in the near-infrared and exhibit new behavior in vivo, including multiple sequential lymph node mapping and extravasation from the vasculature. The biological utility of these fluorescent probes resulted from our intentional choice to match the semiconductor material and water-soluble ligand with a desired final hydrodynamic diameter and emission wavelength.
我们开发了一系列尺寸异常小的水溶性(InAs)ZnSe核壳量子点(QDs),它们在近红外区域发光,并在体内表现出新的行为,包括多个连续淋巴结映射和从脉管系统外渗。这些荧光探针的生物学效用源于我们有意选择将半导体材料和水溶性配体与所需的最终流体动力学直径和发射波长相匹配。