[非甾体抗炎药。声明I。“结构-抗炎作用有效性”的相互关系研究]

[Nonsteroidal anti-inflammatory drugs. Declaration I. A study of interrelation "structure--the effectiveness of anti-inflammatory action"].

作者信息

Khaĭrullina V R, Mukhametov A D, Tiurina L A, Garifullina G G, Gerchikov A Ia, Zarudiĭ F S

出版信息

Biomed Khim. 2007 May-Jun;53(3):266-75.

Abstract

Using the computer system SARD-21 (Structure Activity Relationship & Design) the structural features typical for high- and low- effective nonsteroid anti-inflammatory drugs (NSAIDs) were analyzed. This information has been used for the model for prediction of anti-inflammatory effectiveness of medicines with 76% and 81% level of recognition by two methods. New data can be used for creating new highly effective NSAIDs, and for increasing effectiveness of already known components.

摘要

利用计算机系统SARD - 21（构效关系与设计），分析了高效和低效非甾体抗炎药（NSAIDs）的典型结构特征。该信息已用于药物抗炎效果预测模型，两种方法的识别水平分别为76%和81%。新数据可用于研发新型高效非甾体抗炎药，以及提高已知成分的疗效。