Bornak Arash, Kirksey Lee
Division of Vascular Surgery, Department of Surgery, Graduate Hospital, Philadelphia, PA 19146, USA.
J Natl Med Assoc. 2007 Aug;99(8):933-6.
In 2004, 464,952 individuals were newly diagnosed with chronic renal insufficiency (CRI); 102,356 of those newly diagnosed patients required initiation of dialysis for end-stage renal disease (ESRD). Among the ESRD population, about one third is African American despite the fact that this population represent only about 12% of the total population in the United States (U.S. Renal Data System 2006). Familial aggregation of kidney disease disproportionately affects minorities. This paper describes the detection and management of dialysis access failure due to hypercoagulable states in a genetically related group. We also discuss the implications that associated familial disorders may have on the diagnoses, treatment and survival for this devastating illness.
2004年，有464,952人新被诊断为慢性肾功能不全（CRI）；其中102,356名新诊断患者因终末期肾病（ESRD）需要开始透析治疗。在ESRD人群中，尽管非裔美国人仅占美国总人口的约12%，但约三分之一是该族裔（美国肾脏数据系统，2006年）。肾病的家族聚集现象对少数族裔的影响尤为严重。本文描述了在一个有遗传关系的群体中，因高凝状态导致的透析通路失败的检测与管理。我们还讨论了相关家族性疾病可能对这种毁灭性疾病的诊断、治疗和生存产生的影响。
