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Balancing mucosal immunity: caught between CYLD and Charybdis.

作者信息

Kolls Jay K

机构信息

Children's Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA.

出版信息

Immunity. 2007 Aug;27(2):187-9. doi: 10.1016/j.immuni.2007.08.004.

DOI:10.1016/j.immuni.2007.08.004
PMID:17723213
Abstract

The molecular mechanism of acute lung injury caused by Streptococcus pneumoniae is unclear. In this issue of Immunity, Lim et al. (2007) demonstrate that CYLD, a deubiquinating enzyme, represses the expression of plasminogen activator inhibitor-1, which is critical in preventing tissue damage.

摘要

相似文献

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引用本文的文献

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Toxins (Basel). 2021 Feb 17;13(2):157. doi: 10.3390/toxins13020157.
2
Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses.在髓样单核细胞中截断去泛素化酶 CYLD 的结构域可减弱炎症反应。
PLoS One. 2011 Jan 20;6(1):e16397. doi: 10.1371/journal.pone.0016397.