[白蛋白肝脏透析——分子吸附再循环系统治疗毒鹅膏中毒的疗效评估]

[The assessment of albumin liver dialysis--MARS efficacy in the treatment of Amanita phalloides poisoning].

作者信息

Sein Anand Jacek, Chodorowski Zygmunt, Wiśniewski Marek, Waldman Wojciech

机构信息

Katedra i Klinika Chorób Wewnetrznych, Geriatrii i Toksykologii Klinicznej, Akademii Medycznej w Gdańsku.

出版信息

Przegl Lek. 2007;64(4-5):255-7.

PMID:17724880

Abstract

Fourteen patients were included to the albumin dialysis--MARS in the Clinic of Internal Medicine Geriatry and Clinical Toxicology in the years 2004-2006 because of acute intoxication with Amanita phalloides. The 26 procedures were done. Ten patients recovered, one was transplanted and three patients at the age from 68 to 79 (average 72.6) years died because of acute liver failure (21.4% cases). All deceased patients had significant higher plasma bilirubin level and INR in compare to other probants. The procedures of albumin dialysis caused significant lowering of blood glucose level, red blood cells and platelets, but without the need for intervention.

摘要

2004年至2006年期间，内科老年病学与临床毒理学诊所因急性毒蝇伞中毒，将14名患者纳入白蛋白透析——分子吸附再循环系统（MARS）治疗。共进行了26次治疗。10名患者康复，1名接受了移植，3名年龄在68至79岁（平均72.6岁）的患者因急性肝衰竭死亡（占病例的21.4%）。与其他受试者相比，所有死亡患者的血浆胆红素水平和国际标准化比值（INR）显著更高。白蛋白透析治疗导致血糖水平、红细胞和血小板显著降低，但无需干预。