Jenner Bartosz, Gomółka Ewa
Zakład Toksykologii Analitycznej i Terapii Monitorowanej, Katedry Toksykologii Klinicznej i Srodowiskowej UJ CM.
Przegl Lek. 2007;64(4-5):273-6.
The aim of this paper is epidemiological analysis of poisonings with amphetamine and tetrahydrocanabinols (THC), particularly in three aspects: (1) co-occurrence of other substances (mixed poisonings); (2) factors shaping dynamics in number of poisonings and 3) average age of patients. The data this paper is based on come from the data set "Duch" which is run by the Department of Analytical Toxicology and Drug Monitoring UJ CM in Kraków. The data were collected between 1 Dec. 2001 and 28 Feb. 2005 (1186 days). Amphetamine and THC were determined in patient's urine in semi-quantitative manner by means of EMIT and FPIA methods.
Amphetamine: In the studied period amphetamine was confirmed in 493 patients. Other substances were confirmed in 57.6% of patients: opiates--28.6% THC--14.2%, opiates and THC--5.9%. Since the beginning of the studied period till mid Aug 2003 daily number of cases showed increasing trend (0.062% per day), then the tendency was reversed (-0.074% per day). We observed more males than females (3.24:1). Most cases were poisoned on Mondays, less during the week and least on weekends. At the beginning of the studied period males were older than females (27 vs. 20 years). As the time progressed average age of males was stable but in women average age was increasing at the rate 0.004 year per day. As a consequence of this trend in winter 2004/2005 average age of both sexes was equal. THC: We observed 410 cases with confirmed presence of THC in urine. Other substances were confirmed in 40.2% of patients: amphetamine 17.1% amphetamine and opiates 7.1, opiates 7.1%. There were 17 various substances accompanying THC. In our material the sex ratio was biased toward males (7.8 to 1). Weekly dynamics of poisonings with THC have the same pattern as the one observed in amphetamine. At the beginning of the studied period males were older than females (28 vs. 20 years). Changes in averages followed the same pattern as in amphetamine.
本文旨在对苯丙胺和四氢大麻酚（THC）中毒进行流行病学分析，尤其涉及三个方面：（1）其他物质的共现情况（混合中毒）；（2）影响中毒病例数量动态变化的因素；（3）患者的平均年龄。本文所依据的数据来自克拉科夫雅盖隆大学医学院分析毒理学与药物监测系运行的“Duch”数据集。数据收集时间为2001年12月1日至2005年2月28日（共1186天）。通过EMIT和FPIA方法以半定量方式测定患者尿液中的苯丙胺和THC。
苯丙胺：在研究期间，493例患者的尿液中确认含有苯丙胺。57.6%的患者还检测出其他物质：阿片类药物——28.6%，THC——14.2%，阿片类药物和THC——5.9%。从研究期开始到2003年8月中旬，每日病例数呈上升趋势（每天上升0.062%），之后趋势逆转（每天下降0.074%）。我们观察到男性中毒者多于女性（比例为3.24:1）。大多数中毒事件发生在周一，一周内其他时间较少，周末最少。在研究期开始时，男性中毒者的年龄大于女性（分别为27岁和20岁）。随着时间推移，男性的平均年龄保持稳定，但女性的平均年龄以每天0.004岁的速度增长。由于这种趋势，在2004/2005年冬季，两性的平均年龄相等。THC：我们观察到410例尿液中确认含有THC的病例。40.2%的患者还检测出其他物质：苯丙胺——17.1%，苯丙胺和阿片类药物——7.1%，阿片类药物——7.1%。有17种不同物质与THC同时出现。在我们的样本中，性别比例偏向男性（7.8:1）。THC中毒的每周动态变化模式与苯丙胺中毒的模式相同。在研究期开始时，男性中毒者的年龄大于女性（分别为28岁和20岁）。平均年龄的变化模式与苯丙胺中毒相同。
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