Korkach Iu P, Kotsiuruba A V, Prysiazhna O D, Mohyl'nyts'ka L D, Sahach V F
Fiziol Zh (1994). 2007;53(3):3-8.
Ecdysterone (100 ng/100 g) chronic oral administration (2 months after STZ (5 mg/100 g) administration) normalized plasma glucose levels in rats. This potent hypoglycemic effect of ecdysterone depend on inhibition of non-constitutive NO synthesis by Ca(2+)-independent iNOS and NADP-dependent nitrate reductase as well as inhibition of L-arginine degradation by arginase result in up-regulation of Ca(2+)-dependent constitutive NO synthesis by eNOS or mithochondrial nNOS in heart and aorta of rats.
蜕皮甾酮（100纳克/100克）慢性口服给药（在链脲佐菌素（5毫克/100克）给药2个月后）可使大鼠血浆葡萄糖水平恢复正常。蜕皮甾酮的这种强效降血糖作用取决于通过不依赖钙的诱导型一氧化氮合酶和依赖烟酰胺腺嘌呤二核苷酸磷酸的硝酸还原酶抑制非组成型一氧化氮合成，以及通过精氨酸酶抑制L-精氨酸降解，从而导致大鼠心脏和主动脉中依赖钙的组成型一氧化氮合酶或线粒体神经元型一氧化氮合酶上调组成型一氧化氮合成。
