[Changes in epithelium transport system function and morphological indexes in the colon mucosa of rats with hypergastrinemia of different duration].

The role of gastrin in epithelium water and electrolyte (Na+, K+, CI-) transport in comparison with mucosal morphological indexes (crypt depth, thickness of colonic mucosa and epitheliocytes nuclear profound area) was investigated by using of omeprazole-induced (OM) hypergastrinemia model (for 1-4 weeks) and in vivo perfusing technique in rats. Short-term hypergastrinemia (for 1-2 weeks) caused the alterations in electroneutral absorption of NaCl. Prolongation of hypergastrinemia influence up to 3 weeks had entailed the first manifestation of the trophic effect on colonic mucosa expressed in alterations of electrogenic sodium absorption and increased crypt depth with a thickened colonic mucosa. Prolonged OM-induced hypergastrinemia (for 4 weeks) had led to decreased colonocytes differentiation level with an increased crypt depth, a thickened colonic mucosa and decreased epitheliocytes nuclear profound area which in turn have provoked the decreasing in net water and NaCl absorption.