Béchetoille Alain, Arnould Benoit, Bron Alain, Baudouin Christophe, Renard Jean-Paul, Sellem Eric, Brouquet Yves, Denis Philippe, Nordmann Jean-Philippe, Rigeade Marie-Claude, Bassols Ana, Benmedjahed Khadra, Guillemin Isabelle, Rouland Jean-François
Ophthalmological Practice, Paris, France.
Acta Ophthalmol. 2008 Feb;86(1):71-80. doi: 10.1111/j.1600-0420.2007.00999.x. Epub 2007 Aug 28.
To validate a glaucoma-specific health-related quality of life (HRQoL) questionnaire: the Glau-QoL.
Patients with ocular hypertension (OHT) or glaucoma took part in a cross-sectional psychometric validation study (n = 573) and a separate reproducibility study (n = 244). Patients answered the 36-item Glau-QoL, designed from in-depth patient interviews.
The clinical validity of the Glau-QoL was excellent and clearly demonstrated that as disease severity and visual field impairment increased, HRQoL scores for the Psychological Wellbeing, Self-image, Daily Life, Driving, Anxiety and Burden of Treatment domains were negatively affected. Increased age and lower visual acuity were also associated with lower HRQoL scores, although to a lesser extent than the previously mentioned criteria. Worsening of HRQoL domains correlated with the clinical stage of glaucoma: Anxiety and Burden of Treatment scores dropped noticeably when patients were first diagnosed and started treatment, followed by a decrease in scores for Driving, Daily Life, Psychological Wellbeing, and Self-image as clinical conditions worsened. Psychometric validation showed acceptable convergent and discriminant validity of the Glau-QoL, and good reproducibility, with intraclass correlation coefficients (ICC) and concordance correlation coefficients (CCC) > or = 0.69. Internal consistency reliability was high (Cronbach's alpha coefficients > 0.70) for the Daily Life, Psychological Wellbeing, Burden of Treatment and Driving domains; acceptable (coefficients of 0.65 and 0.68, respectively) for the Self-image and Anxiety domains; and weak (coefficient = 0.58) for the Confidence in Health Care domain.
The Glau-QoL questionnaire is a valid and specific HRQoL instrument that demonstrates excellent correlations with disease progression in patients with glaucoma and/or OHT.
验证一种青光眼特异性的健康相关生活质量（HRQoL）问卷：青光眼生活质量问卷（Glau-QoL）。
高眼压症（OHT）或青光眼患者参与了一项横断面心理测量学验证研究（n = 573）和一项单独的重复性研究（n = 244）。患者回答了基于深入患者访谈设计的36项Glau-QoL问卷。
Glau-QoL的临床效度极佳，清楚地表明随着疾病严重程度和视野损害增加，心理健康、自我形象、日常生活、驾驶、焦虑和治疗负担领域的HRQoL得分受到负面影响。年龄增加和视力下降也与较低的HRQoL得分相关，尽管程度小于上述标准。HRQoL领域的恶化与青光眼临床分期相关：患者首次诊断并开始治疗时，焦虑和治疗负担得分显著下降，随后随着临床病情恶化，驾驶、日常生活、心理健康和自我形象得分下降。心理测量学验证显示Glau-QoL具有可接受的收敛效度和区分效度，以及良好的重复性，组内相关系数（ICC）和一致性相关系数（CCC）≥0.69。日常生活、心理健康、治疗负担和驾驶领域的内部一致性信度较高（Cronbach's α系数>0.70）；自我形象和焦虑领域可接受（系数分别为0.65和0.68）；医疗保健信心领域较弱（系数 = 0.58）。
Glau-QoL问卷是一种有效且特异的HRQoL工具，与青光眼和/或高眼压症患者的疾病进展具有极佳的相关性。
