糖尿病患者的食管动力障碍、胃排空延迟及胃肠道症状

Oesophageal dysmotility, delayed gastric emptying and gastrointestinal symptoms in patients with diabetes mellitus.

作者信息

Faraj J, Melander O, Sundkvist G, Olsson R, Thorsson O, Ekberg O, Ohlsson B

机构信息

Gastroenterology Division, Department of Clinical Sciences, Malmö University Hospital, Lund University, Lund, Sweden.

出版信息

Diabet Med. 2007 Nov;24(11):1235-9. doi: 10.1111/j.1464-5491.2007.02236.x. Epub 2007 Aug 24.

Abstract

AIMS

Gastroparesis is a common gastrointestinal complication in diabetes mellitus, whereas dysfunction in the other gastrointestinal organs has been less thoroughly investigated. Furthermore, it is not known whether there is any relationship between motility and dysmotility between these organs. The aim of this study was to examine whether diabetic patients with gastrointestinal symptoms also have motility disturbances in the oesophagus and stomach and, if so, whether there are any associations between these disturbances.

METHODS

Thirty-one patients with diabetes mellitus who complained of gastrointestinal symptoms were asked to complete a questionnaire about their symptoms. They were further investigated with oesophageal manometry and gastric emptying scintigraphy.

RESULTS

Fifty-eight per cent of the patients had abnormal oesophageal function, and 68% had delayed gastric emptying. Abdominal fullness was the only symptom that related to any dysfunction, and it was associated with delayed gastric emptying (P = 0.02). We did not find any relationship in motility or dysmotility between the oesophagus and the stomach.

CONCLUSION

Oesophageal dysmotility, as well as gastroparesis, are common in patients with diabetes who have gastrointestinal symptoms. It is important to investigate these patients further, to be able to reach an accurate diagnosis and instigate appropriate treatment. Our findings indicate that the oesophagus and the stomach function as separate organs and that pathology in one does not necessarily mean pathology in the other.

摘要

目的

胃轻瘫是糖尿病常见的胃肠道并发症,而其他胃肠道器官的功能障碍尚未得到充分研究。此外,这些器官的动力与动力障碍之间是否存在关联尚不清楚。本研究的目的是检查有胃肠道症状的糖尿病患者食管和胃是否也存在动力障碍,以及如果存在,这些障碍之间是否存在关联。

方法

31例有胃肠道症状的糖尿病患者被要求填写一份关于其症状的问卷。他们还接受了食管测压和胃排空闪烁扫描检查。

结果

58%的患者食管功能异常,68%的患者胃排空延迟。腹胀是唯一与任何功能障碍相关的症状,且与胃排空延迟有关(P = 0.02)。我们未发现食管和胃在动力或动力障碍方面存在任何关联。

结论

食管动力障碍以及胃轻瘫在有胃肠道症状的糖尿病患者中很常见。进一步对这些患者进行检查很重要,以便能够做出准确诊断并采取适当治疗。我们的研究结果表明,食管和胃作为独立的器官发挥功能,一个器官的病变不一定意味着另一个器官也有病变。

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