载脂蛋白E基因型以性别特异性方式影响1型单纯疱疹病毒的垂直传播。

Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner.

作者信息

Burgos Javier S, Ramirez Carlos, Sastre Isabel, Valdivieso Fernando

机构信息

NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain.

出版信息

Aging Cell. 2007 Dec;6(6):841-2. doi: 10.1111/j.1474-9726.2007.00332.x. Epub 2007 Aug 24.

DOI:10.1111/j.1474-9726.2007.00332.x

PMID:17725689

Abstract

There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD.

摘要

越来越多的证据表明，1型单纯疱疹病毒（HSV-1）与载脂蛋白E4（APOE4）等位基因共同促成了阿尔茨海默病（AD）的发病机制，尽管它们相互作用的机制仍不明确。在此我们表明，遗传性APOE基因型与HSV-1的垂直传播相结合会带来不同的脑部感染风险。已知这些风险因素与AD相关。