Department of Medicine, University of Washington, Seattle, Washington 98102, USA.
Sex Transm Infect. 2010 Jun;86(3):202-6. doi: 10.1136/sti.2009.039735. Epub 2010 Apr 21.
Apolipoprotein E is polymorphic in the human population. APOE4 has previously been reported to correlate with symptomatic oral and genital herpes disease.
APOE was genotyped in 182 subjects with herpes simplex virus (HSV) 2 and in 62 subjects with HSV-1, including 44 subjects with both viral types for a total of 200 adults. HSV shedding was measured by PCR from swab samples obtained daily from mucosa for at least 30 days. Participants also maintained a diary of oral or genital lesions.
The APOE genotypes observed reflected the US white population and the Hardy-Weinberg equilibrium. Genital and oral HSV shedding was detected on 17.2% and 3.7% of overall days, respectively, whereas genital and oral lesion rates were 10.1% and 2.9%. Using Poisson regression and adjusting for known correlates of HSV shedding, a significant association was not observed between the APOE genotype and genital or oral HSV shedding, or genital HSV lesions. However, the presence of the APOE4 allele was associated with a higher rate of oral herpetic lesions, with a relative risk of 4.64 (95% CI 1.32 to 15.05, p=0.016).
Variation at the APOE locus may be associated with clinical manifestations of HSV-1 infection, but does not appear to correlate with herpes simplex viral reactivation in humans.
载脂蛋白 E 在人类群体中存在多态性。先前已有报道称 APOE4 与症状性口腔和生殖器疱疹病相关。
对 182 例单纯疱疹病毒 2（HSV-2）和 62 例单纯疱疹病毒 1（HSV-1）患者进行 APOE 基因分型，包括 44 例同时感染两种病毒的患者，共计 200 例成年人。通过从粘膜拭子样本中每日进行 PCR 检测来测量 HSV 脱落。参与者还记录了口腔或生殖器病变的日记。
观察到的 APOE 基因型反映了美国白人人群和 Hardy-Weinberg 平衡。分别在 17.2%和 3.7%的总天数中检测到生殖器和口腔 HSV 脱落，而生殖器和口腔病变发生率分别为 10.1%和 2.9%。使用泊松回归并调整已知的 HSV 脱落相关因素后，APOE 基因型与生殖器或口腔 HSV 脱落或生殖器 HSV 病变之间未观察到显著关联。然而，APOE4 等位基因的存在与口腔疱疹病变的更高发生率相关，相对风险为 4.64（95%CI 1.32 至 15.05，p=0.016）。
APOE 基因座的变异可能与 HSV-1 感染的临床表现相关，但似乎与人类单纯疱疹病毒再激活无关。
