Stöllberger C, Krugluger W, Winkler-Dworak M, Finsterer J
Int J Cardiol. 2008 Oct 30;130(1):84-6. doi: 10.1016/j.ijcard.2007.05.065. Epub 2007 Aug 28.
Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality with suspected genetic background, characterized by trabeculations and intertrabecular recesses. Aim of the study in LVHT patients was to assess the AB0 system and D(Rh(o)) antigen frequencies, to look for an association between the prevalence of cardiac and neuromuscular abnormalities and to compare distribution of the AB0 system and D(Rh(o)) antigen frequencies with the Austrian general population.
In 77/102 LVHT patients (75%) information about blood group could be obtained. There were no differences in the prevalence of clinical, electrocardiographic and echocardiographic findings and neuromuscular disorders between the AB0 blood groups. When comparing 67 LVHT patients who were D(Rh(o)) antigen positive with 10 patients who were D(Rh(o)) antigen negative, no differences could be found. Among LVHT patients, 0 D(Rh(o)) antigen positive was the most frequent (39%) followed by A D(Rh(o)) antigen positive (34%). In the Austrian general population A D(Rh(o)) antigen positive was the most frequent (33%) followed by 0 D(Rh(o)) antigen positive (30%).
This study shows that LVHT patients do not differ according the blood groups, and that the distribution of blood groups is only minimally different between LVHT patients and the general Austrian population.
左心室致密化不全（LVHT）是一种具有遗传背景嫌疑的心脏异常，其特征为肌小梁和小梁间隐窝。本研究针对LVHT患者的目的是评估ABO系统和D（Rh（o））抗原频率，寻找心脏和神经肌肉异常患病率之间的关联，并将ABO系统和D（Rh（o））抗原频率的分布与奥地利普通人群进行比较。
在102例LVHT患者中的77例（75%）可获取血型信息。ABO血型之间在临床、心电图、超声心动图检查结果及神经肌肉疾病的患病率方面无差异。将67例D（Rh（o））抗原阳性的LVHT患者与10例D（Rh（o））抗原阴性的患者进行比较时，未发现差异。在LVHT患者中，D（Rh（o））抗原阴性最为常见（39%），其次是D（Rh（o））抗原阳性A型（34%）。在奥地利普通人群中，D（Rh（o））抗原阳性A型最为常见（33%），其次是D（Rh（o））抗原阴性O型（30%）。
本研究表明，LVHT患者在血型方面无差异，且LVHT患者与奥地利普通人群之间血型分布仅有极小差异。
