钯催化、铜（I）介导的芳基硼酸与2（1H）-吡嗪酮的交叉偶联反应，通过微波辐射并同时冷却来促进。
Palladium-catalyzed copper(I)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling.
作者信息
Singh Brajendra Kumar, Mehta Vaibhav Pravinchandra, Parmar Virinder Singh, Van der Eycken Erik
机构信息
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001, Heverlee/Leuven, Belgium.
出版信息
Org Biomol Chem. 2007 Sep 21;5(18):2962-5. doi: 10.1039/b704389a. Epub 2007 Aug 6.
DOI:10.1039/b704389a
PMID:17728862
Abstract
The application of a palladium-catalyzed Cu(I)-mediated Liebeskind-Srogl protocol for the decoration of the 2(1H)-pyrazinone scaffold resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling.
摘要
在同时冷却的微波辐射条件下，应用钯催化、铜（I）介导的利伯斯金德-施罗格尔反应方案对2(1H)-吡嗪酮骨架进行修饰，可显著提高产率和反应速率。
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